Established in 1927 and designed by the renowned architect Charles R. Weatherhogg (1872–1937), North Side High School has a longstanding commitment to providing exceptional education. The school's gym, once the home of the Fort Wayne Pistons of the Basketball Association of America (later the National Basketball Association) from 1941 to 1952, bears witness to its rich history.
North Side High School proudly hosts the Global Studies/World Languages Program of Study, integrating global knowledge into its courses. This approach equips students with the skills to navigate and thrive in a global society, emphasizing the interconnectedness of people and institutions worldwide. The program delves into the interdependence of global economic, political, technological, environmental, and social systems.
Home to the Vincennes Early College Program, North Side offers a unique four-year initiative enabling students to earn both college and high school credits through a challenging curriculum. Early college students can even obtain an Associates Degree in Global Studies with a focus on Spanish before graduating high school.
The school provides honors programs in English 9 and 10, Algebra I, Algebra II, Geometry, Biology, and Chemistry. Additionally, North Side offers dual-credit opportunities in various other subjects, including Composition, Pre-Calculus, Calculus, Psychology, Biology, Chemistry, Physics, U.S. history, World History, Art, Economics, French 4, Drawing, Government, Manufacturing/Logistics, and Digital Design.
Students at North Side have a wealth of extracurricular activities to choose from, including the award-winning marching band, jazz band, show choir, drama, dance, and robotics club. The school is also proud to offer the English Language Learner (ELL) program for those whose first language is not English. Boasting a diverse student body, North Side welcomes students from at least 18 countries who collectively speak at least 29 different languages. Prospective students typically transition from Lakeside and Northwood middle schools, and the school is situated in the Board of School Trustees District 2.